
Prof. M. Zubair Iqbal
Zhejiang Sci-Tech University, China
Title: Metal-Free Organo-Theranostic Nanomicelles for MRI and Tumor Photo-Immunotherapy
Abstract:
Present-day theranostic agents for tumor magnetic resonance imaging (MRI) and photothermal therapy are generally metal-based with attendant metal-specific downsides. We therefore designed a tumor-targeted all-organic nanotheranostic platform by effectively compartmentalizing organic nitroxide radicals in polymeric nanoparticles via amide-bond linkages. The nanoplatform features prolonged nitroxide-systemic circulation times, appreciable water dispersibility, high nitroxide loading and in vivo reduction resistance, superlative biocompatibility, and ultimate magnetic resonance-imaging sensitivity. Moreover, the metal-free folate-targeted nanoplatform conveys a plethora polypyrrole to tumor sites for effectual MRI-guided tumor-targeted photothermal therapy. It is therefore envisaged that leveraging the underlying benefits of this study will help to guide the design of future all-organic-based nanoparticles in furtherance to safer tumor theranostics.
Biography:
Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Vice President, Materials Science Society of Pakistan
Vice-Director, Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering
Visiting Professor, NIMTE, Chinese Academy of Sciences
M. Zubair is currently working as a Professor at the Institute of Biomedical Materials at Zhejiang Sci-Tech University, China, and visiting Professor at Ningbo Institute of Materials Technology & Engineering (NIMTE), Chinese Academy of Sciences (CAS) with the title of Overseas High-Level Expert of Zhejiang Province. He is also serving as a Vice Director at the Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering and Vice President of the Materials Science Society of Pakistan. His research interests involve the fabrication of highly biocompatible bio-nano materials for cancer diagnosis, drug delivery, and therapeutic applications. He has published over 150 research articles in reputed international journals, such as ACS Nano, Biomaterials, Small, Advanced Healthcare Materials, Journal of Controlled Release, Nano Research, Applied Materials Today, Journal of Materials Chemistry B, etc., and has several innovative patents, scale-up experience in the industry, won several competitive research grants from Zhejiang Science Foundation and National Natural Science Foundation of China, a reviewer/editor of many journals and participated in numerous international conferences as an invited and keynote speaker.