Prof. Pubali Dhar
University of Calcutta, India
Title: Biodelivery of soft matter nanomaterials
Abstract:
Soft matter exists in different forms; for example, self-assembled organ-ic nanotubes, nanofibers, gels, liquid crystals, nanoemulsions, hydrocolloids and polymers. Bioactivity of food and drug nanomaterials depend on the bioavailability ans bioaccessibility to the cells and tissues. The physiological efficacy of nutraceuticals or drugs encapsulated in nanoparticles or nanomaterials is dependent on their physicochemical nature and bioavailability across biological barriers. Nano-sizing of emulsion-based delivery vehicle determines the bioa-vailability of nutraceuticals or the drug. It can be investigated via three-step experimental design; ex vivo rat everted intestinal sac model, in vivo bioactivity, cellular lipid uptake and the bioactivity in Peripheral Blood Mononuclear Cells. Nanoemulsion in comparison to the conven-tional emulsion shows significant higher rate of uptake of the encapsu-lated materials in three segments of small intestine. The time-kinetics of such uptake of PUFA was correlated with appearance of SFAs in basal side of the everted sac. The short-term effect of the nano formulations of eleostearic acid rich oil (ESA) in the isolated human PBMCs challenged with and without lipopolysaccharide (LPS) for cell-surface bio-marker (CD 14, CCR5/CD195) expressions, also revealed novel findings. The findings of this study emphatically indicate that ESA plays a mul-ti-prong role in circumventing stressed conditions by influencing the nodes of redox signaling and also by rectifying molecular parameters associated with genomic stability which gets compromised as a conse-quence of pro-inflammatory stimulus. These findings reinforces the prophylactic and therapeutic potential of ESA with compelling data and evidences of property function rendered by tailored formulations. The formulation with nano-sized droplets can be utilized as smart deliv-ery vehicles for designing oral therapies in future.
Keywords
Nanoemulsions, bioavailability, bioaccessability, bioactivity, nutraceuticals
Biography:
Dr. Pubali Dhar is an eminent food scientist and has a research team primarily engaged in exploring different aspects of nanoformulations with nutraceuticals, production of functional food and lipid technology. She is having an h-index of 12, i10 index of 17 and >50 publications in International peer-reviewed high-impact journals with over 578 citations and substantial teaching experience of more than 17 years at both graduate and post-graduate level. She is supervising PhD thesis of over 8 students presently and has also supervised 10 doctoral students in the recent past.