Dr.  Liang  Zheng
Tongji University,  China

Title: The evaluation of predicting value of baPWV and hs-crp to ASCVD in community population in China

Abstract:

Introduction: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality globally. However, there was still not a simple and stable screening predictor to ASCVD in community population.

Hypothesis: To estimate the prevalence of ASCVD in middle and elderly community population in Shanghai. To evaluate the screening value of baPWV and hs-crp to ASCVD.

Methods: Simple linear correlation was adopted to indicate the relationship between different variables; ROC curve analysis was used to compare the screening value between baPWV and hs-crp predicting ASCVD. Logistic regression was conducted to explore the risk factors of ASCVD.

Results: 1150 subjects were included in Lujiazui community, Shanghai, and 1065 individuals had completed data including of 295 men and 770 women. The mean of age, BMI, SBP, BNP and baPWV were significantly higher in ASCVD group while TG was higher in non-ASCVD group (P<0.05). As for constituent ratio, there were differences on smoking and drinking between two groups (P<0.05). On the other hand, the prevalence of ASCVD was 12.58% in target population.

There were significant relationship between baPWV and age (r=0.49)/SBP(r=0.56) /WC(r=0.15), while there were no significant relationship between baPWV and hs-crp (r=0.04). ROC curve analysis indicated the screening value of baPWV and hs-crp to ASCVD. The AUC and its 95%CI was 0.65 and 0.61–0.71 for the baPWV and 0.59 and 0.53–0.65 for hs-crp. Compared with hs-crp, the screening value of baPWV was more significant to discriminate the ASCVD.

When adjusted variables were gender and baPWV, the logistic regression (model 1) showed that higher baPWV (over 1550 cm/s) was a risk factor for ASCVD (OR: 1.53 and 95% CI: 1.04–2.27) comparing to lower baPWV under 1350 cm/s. In model 2, overweight and higher baPWV entered the final regression equation after adjusting gender, marital, overweight, drinking and baPWV.

Conclusions: The prevalence of ASCVD was 12.58% in target population in Shanghai, China. Compared with hs-crp, the screening value of baPWV was more significant to discriminate the ASCVD. Overweight and higher baPWV rank (≥1550 cm/s) were risk factors to cause the ASCVD when adjusting gender, marital, BMI, drinking status and baPWV.

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