Prof. Islam Al Dababsekh
I.D.Stem Cells and Genome Institute, Ukraine
Title: In Vitro Differentiation of Bone Marrow Mesenchymal Stem Cells into Human Male Gametes
Abstract:
Introduction
Infertility is a prevalent concern globally, with male infertility, including conditions like azoospermia, posing significant challenges. Conventional treatments are limited, prompting interest in stem cell therapies. In the MENA region, high infertility rates underscore the need for accessible treatments. This study explores using MSCs to generate spermatocytes, potentially revolutionizing male infertility treatments by leveraging advancements in stem cell technology.
Literature Review
The study builds on global research exploring stem cell solutions for infertility. Unlike studies on animal tissues or specific germ cells, our focus on human-derived MSCs bridges critical gaps in applicability. Previous studies on SSCs and BM-SCs highlight their potential but underscore challenges in scalability and clinical translation, contrasting with our approach using readily available MSCs.
Materials and Methods
MSCs were mobilized from bone marrow using granulocyte colony-stimulating factor (G-CSF) and differentiated in vitro under controlled conditions. Key markers of meiosis progression such as DMC1, DAZL, Oct-4 were monitored, culminating in the development of functional spermatocytes suitable for IVF attempts.
Results
The study successfully differentiated MSCs into mature spermatocytes capable of fertilizing oocytes. Outcomes included viable embryos developed from fertilized oocytes and preserved for future use, highlighting the efficacy of MSC-derived gametes in reproductive technologies.
Discussion
Compared to conventional approaches focusing on SSCs or animal-derived stem cells, our study introduces MSCs as a versatile source for generating functional gametes. This approach addresses practical limitations associated with existing methods and opens new avenues for personalized infertility treatments.
Conclusion
This study demonstrates MSCs' potential to revolutionize male infertility treatments by producing functional spermatocytes. Further optimization and clinical validation are crucial to enhance the efficacy of MSC-based therapies, offering new hope to individuals and couples globally affected by infertility.
Biography:
Prof. Islam Al-Dababsekh is a distinguished medical professional and researcher specializing in regenerative medicine, genetics, and stem cell therapies. As the Director of I.D. Stem Cells and Genome Institute and founder of I.D. Medical Group, he combines clinical expertise with innovative research to pioneer advancements in stem cell-based treatments.
With a Ph.D. in cardiovascular surgery and professorship in genetics, Prof. Al-Dababsekh’s career spans over two decades. His diverse medical expertise includes general, vascular, and endovascular surgery, as well as dermatology. He has contributed significantly to the field through clinical practice, groundbreaking patents, and international presentations.
A member of ISSCR and other prestigious associations, he has been at the forefront of regenerative medicine since 2017, focusing on cutting-edge therapies to enhance human health. Prof. Al-Dababsekh’s commitment to advancing science is reflected in his leadership roles, research, and dedication to improving patient outcomes worldwide.