Prof.  Masoumeh  Ghalkhani
Shahid Rajaee Teacher Training University,  Iran

Title: Rapid quantitative detection of medetomidine using an electrochemical sensor based on CNOs boosted with metal sulfide and polymeric-based nanocomposite

Abstract:

Medetomidine, 4-[1-(2,3-dimethylphenyl) ethyl]-1himidazole hydrochloride, is a synthetic drug that is prescribed as a surgical anesthetic and sedative. This drug has analgesic effects too. In this work, a screen-printed carbon electrode (SPCE) was modified by a composite of N and P-doped carbon nano-onions (N, P CNO), MoS2, and poly (melamine) (PME) (SPCE/N, P CNO/MoS2/PME). First, synthesized nanomaterials and fabricated electrodes were evaluated and analyzed by FT-IR, FE-SEM, and XRD techniques. Then, the voltammetric response of medetomidine was evaluated using SPCE/N, P CNO/MoS2/PME. The effect of N, P CNO, MoS2, and melamine, deposited electrochemically on the surface of SPCE, was evaluated for medetomidine measurement. Results proved that the mentioned nanomaterials enhanced the SPCE surface area and facilitated the electron transfer rate. A cathodic peak appeared in a buffered solution with pH = 7.0 containing medetomidine. A diffusion-controlled process resulted in the medetomidine electroreduction at SPCE/N, P CNO/MoS2/PME. The synergetic effect of N, P CNO, and MoS2, providing wide active surface area, and PME as an electron conduction booster enhanced the modified electrode response toward medetomidine. The calculated detection limit for medetomidine in the concentrations range of 0.04 to 700 μM was 10 nM. The SPCE/N, P CNO/MoS2/PME was able to determine accurately the medetomidine concentration in mouse blood samples with 90-98.2% recovery. The consecutive analysis of a medetomidine solution led to outstanding repeatability with RSD = 4.10%. The calculated RSD = 3.54% for the reproducibility test of SPCE/N, P CNO/MoS2/PME preparation introduced it as a proper sensor. The long-term stability is another outstanding feature of the SPCE/N, P CNO/MoS2/PME, for which a 23% decrement of the peak current resulted after 6 months of storage.

Keywords: Medetomidine, Carbon nano anions, MoS2, Melamine, N doped, P doped

Biography:

Dr. Masoumeh Ghalkhani began her career at the top university in Iran- Sharif University of Technology (SUT) where she obtained her M.Sc. (2005) and received her PhD in Electrochemistry (2010). In Sep. 2012, she was appointed Assistant Professor in Chemistry at Shahid Rajaee Teacher Training University, SRTTU, Iran. At present, she is an Associate Professor of Chemistry at SRTTU. Her current research interests include chemistry education, synthesis of nanomaterials and their application for electro-analytical chemistry, electro-chemical catalysis, fuel cells, supercapacitors, and sensors, mainly focused on the fabrication and application of modified electrodes and biosensors. She has published over 100 manuscripts related to electrochemical systems, catalysis, and inorganic chemistry that have garnered over 4511 citations.