With the deepening of national digital transformation and the “Healthy China” initiative, non-invasive wearable sensing technologies are emerging as a research frontier in the field of health management. Ultra-sensitive wearable sweat analysis platforms that integrate flexible electronics, microfluidics, and electrochemical analysis enable real-time and continuous monitoring of physiological and metabolic signals, offering new opportunities for early disease screening, personalized diagnosis, and proactive health management. Sweat, as a biofluid rich in diverse biomarkers, reflects key physiological parameters such as metabolic status and hormone levels. Its non-invasive and continuously accessible nature makes it especially valuable for the digital and intelligent management of women’s health. For instance, fluctuations in female hormone levels are closely associated with fertility, menstrual disorders, and menopause, and are critical for monitoring, intervention, and therapeutic evaluation in conditions such as infertility, polycystic ovary syndrome (PCOS), and menopausal transition. This report focuses on the precise detection of ultra-low concentration biomarkers in sweat, introducing the development of high-performance sweat sensing platforms from the perspectives of molecular recognition mechanisms, microfluidic chip design, and wearable system integration. It systematically reviews recent advances in sensor sensitivity, selectivity, and stability, and highlights strategies to address challenges such as signal interference, miniaturization, and long-term wearability. Furthermore, it explores the promising applications of these platforms in the digital and intelligent management of women’s health, particularly in scenarios requiring continuous, real-time hormone monitoring for reproductive health tracking, menstrual cycle analysis, early diagnosis of endocrine disorders, and personalized intervention.

Dr. Cui Ye completed her postdoctoral training at the California Institute of Technology (Caltech) in early 2025 and subsequently joined Shanghai Jiao Tong University as an independent Principal Investigator, doctoral supervisor, and discipline leader, where she leads the Flexible Sensing and Proactive Health research group. She is a recipient of China’s National High-Level Young Talent Program and the Shanghai Magnolia Young Talent Program. Her research centers on flexible electronic sensing technologies, with particular emphasis on wearable biosensors, noninvasive sweat monitoring, electrochemical analysis, microfluidics, and personalized digital health management. Dr. Ye has published over 50 peer-reviewed articles, receiving more than 4,850 citations with an h-index of 32. As a first or corresponding author, she has authored 22 publications in leading journals including Nature Nanotechnology, Nature Materials, and Chemical Society Reviews, with her work highlighted by Nature and other major scientific outlets. Dr. Ye has led three national and provincial research projects and holds four authorized Chinese patents and one international patent, which has been licensed and supported by external funding. She also received the MINE Distinguished Young Scientist Award. She currently serves as a Youth Editorial Board Member of The Innovation, Med-X, and Soft Science.