Dr.  Vinod Kumar  Tiwari
Banaras Hindu University,  India

Title: ‘Click Chemistry’- A Nobel Prize Reaction: The Growing Impact in Glycoscience

Abstract:

Just after the discovery of ‘CuAAC - Click Chemistry’ by K B Sharpless and M Meldal in 2002, this regioselective reaction is widely explored in various emerging fields of chemistry, biology, medicine, and material science.¹ It just says ‘click’ and the molecules can coupled together through 1,2,3-triazole as biologically imperative linker. The protocol is reached to a highest recognition as 2022 Nobel Prize in Chemistry awarded to Prof. C R Bertozzi, K B Sharpless, and M. Meldal for ‘the development of click chemistry and biorthogonal chemistry’. Bertozzi has engaged this tool to a new dimension through using it in living organisms,² a perception widely explored in chemical biology and drug development. A clear understanding of the role of carbohydrate in a number of important biological events has led to their increased demand for the complete chemical, biological, and pharmacological investigations. Through utilizing this modular CuAAC tool, tremendous efforts have been made during the last 21 years to furnish diverse range of the desired triazole-appended molecular architectures. In this context, CuAAC mediated synthesis of diverse potent glycohybrids and glycodendrimers achieved in my laboratory^3-8 will be presented in great detail.

Biography: